In this work, a multifunctional cotton fabric was developed by immobilizing titanium dioxide nanoparticles (tio2-nps) using an eco-friendly bath (citric acid as spacer, and sodium hypophosphite as catalyst). this was achieved by employing textile industry techniques and assessing systematically the effects of nanoparticles, spacer and catalyst concentrations on the finishing bath along different curing temperatures. analysis of variance (anova) and surface response methodology (srm) were used to investigate multiple cycles of methylene blue photocatalytic degradation and flame retardancy. the results disclosed an excellent performance of the treated fabric for various applications: flame retardant (char content enhanced by 1000%), photocatalyst for dye solution removal (>90% of contaminant abatement and feasibility for multiple reuses), self-cleaning agent for intense stains (up to 80% of stain vanishing), bacterial inhibition in dark conditions (~25%). moreover, those properties were maintained after at least 5 washing cycles.